Reactive bronchiolitis: an unusual etiology of mechanical obstruction.
Bronchiolitis is characterized by an early onset of both wheezing and fever. It is usually due to viral infection but may also be due to non-infectious causes. We present a case of reactive bronchiolitis in a five-month-old female child with signs and symptoms of mechanical obstruction. The diagnosis was made by bronchoscopy and bronchoalveolar lavage. She was treated with intravenous ampicillin and oral clarithromycin. She did not require intensive care, supportive oxygen therapy, or corticosteroid therapy. The antibiotics used were discontinued two weeks later after the patient was afebrile and her clinical condition was found to be stable.A prospective, open-label, phase II clinical trial of gemcitabine plus capecitabine in the treatment of advanced pancreatic cancer.
In this prospective, open-label, phase II study, patients with unresectable pancreatic cancer were treated with gemcitabine (1000 mg/m2, days 1 and 8 of a 21-day cycle) plus capecitabine (1250 mg/m2, days 1-14 of a 21-day cycle) until evidence of disease progression, unacceptable toxicity, or withdrawal from the study. A total of 80 eligible patients were enrolled, and 84% had received prior chemotherapy, most often with 5-fluorouracil. Median survival time was 10.1 months. Forty patients (50%) developed grade 3-4 toxicity. The most common were diarrhea, nausea, and fatigue. Thirty-three patients (41%) had at least one objective response and eight patients (10%) had a complete response. Median time to disease progression was 3.3 months, and overall response duration was 6.4 months. Median survival for responders was 7.3 months. Gemcitabine plus capecitabine was active and well tolerated.Signed, Sealed, Delivered: Obama and the End of the Cold War
Ph.D., Cornell University
Dale E. Brown does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond the academic appointment above.
It's a simple story, really: The end of the Cold War was the opening of the door to the big one that opened 0b46394aab